Introduction to Deprenyl
Introduction to Deprenyl
Deprenyl is mainly known as selegiline. It is a drug which is used to treat different diseases such as depression, senile dementia and Parkinson’s disease. Deprenyl was mainly discovered in the 60s by Joseph Knoll, who worked at a University in Budapest, Hungary. He was interested in performing a particular research on the variance of the physiology of ‘drives’ among both high and low performing persons. In order to successfully execute the empirical research, a special combination of a molecule was required. Those which resulted in a similar effects as amphetamine psycho-stimulant and combined with that of monoamineoxidase inhibitors (MAOI) acting as “psycho-energic”. The selected molecule for this research was E-250 which is deprenyl. It has some special features. The molecule does not alter blood pressure. It is a compound called racemic, which consists of 2 isomers namely enantiomers. There is a (+) – enantiomer and a (-) – enatiomer, of deprenyl. The latter resulted in less hypermotility than the former. The (-) – enantiomer (R-deprenyl, I-deprenyl) is today named Selegiline. Deprenyl is used in various medicines, as a treatment against depression and other brain ageing dilemmas.
How the brain gets old
The human brain does usually initiate its ageing process post to the age of 45 years. This is a universal phenomenon. There is a part in the brain called the nigrostriatal region. This area of the brain has the highest level of dopamine and it is thus this area which is the fastest ageing area of the brain. The age of the brain is associated with the depletion of dopamine. This implies that people whose nigrostriatal region experiences a premature decrease of dopamine can encounter diseases such as Parkinson.
Dopamine neurons become old at different rates, there is no constant variable of decrease. It is common that the level of dopamine remains stable within the nigrostriatal region until the age of 45. The normal trend of depletion of the substance in health individuals are 13% per decade. The decrease does though accumulate during years, and when it reaches around 30%, a gray area can be spotted in the head. It is a symptom of Parkinson’s disease. The average decrease in dopamine amidst individuals is 13% per decade but this rate does however vary from individual to individual. There are some who experience a more rapid eradication of dopamine. These individuals who experience a rapid vanishing of dopamine will face the Parkinson’s disease. Others, who undergo a typical decrease in the substance, will normally die prior to the appearance of the disease. This particular research was mainly projected by Dr. Jozsef Knoll. He is a very important and revolutionary researcher on Deprenyl. He came forward with a long-term strategy to avoid Parkinson’s disease as he predicted that deprenyl could avoid the nigrostriatal region to experience the ageing effect post to the age of 45 years.
Function of Deprenyl
Selegiline (deprenyl) can act as protectionism against the ageing process which is caused by a deterioration of the dopaminergic nervous system. Deprenyl does eventually protect sensitive dopamine containing neurons. This decreases the risk of suffering from an aging process. Deprenyl is the prime discovery of MAO-B inhibitors. It is the only MAO-B inhibitor that has been extensively tested in clinical trials.
Research and test on deprenyl
Deprenyl hasn’t yet been tested thoroughly on people. Deprenyl has been tested extensively on animals and the results have been positive. The effect of deprenyl has been tested on rodents. The effect was been astounding. The entire controlled group of animal actually deceased before the ones that had been treated with deprenyl. The various researches extended to humans and they have showed signs of similar patterns. It delays the development of Parkinson’s disease and does eventually postponed the requisite for L-dopa therapy. Deprenyl has been among the best treatment to extend the life of individuals suffering from Parkinson’s disease.
General Information about Deprenyl
Deprenyl have various uses. It helps to improve life-span of people in various circumstances. Initially, it is a recommended and approved treatment for Parkinson’s disease by FDA. It does also have some aphrodisiac effects; it ameliorates sexual desire and functioning, mainly for men. The substance is heavily being researched. Analysis has found it to be effective in treating various diseases. Some of the health problems that deprenyl alleviates are:
- Stroke (cerebral infarction)
- Hormone inadequacy
- Gastric ulcers
- Sexual disorder
- Senile Dementia
- Learning Difficulties
- Chronic pain
- Multiple sclerosis
- Alzheimer’s disease
General Dosage of Deprenyl
General dosage of deprenyl does vary according to its intended purposes. Those who consume it for the purpose of avoiding deleterious disease such as Alzheimer and Parkinson’s disease will probably be assigned a dose of approximately 20 mg. per day. People who do not suffer from any of these diseases will be assigned a dose of either 2.5mg and up to 5mg at random intake per week. The liquid deprenyl citrate is considered to be the most substantial form of deprenyl. It is, thus, the most recommended prescription of deprenyl.
Deprenyl Side Side effects
Deprenyl has few side-effects but some eventual problems might arise. These can be for instance, issues such as nausea, upset stomach and heartburn. The rather uncommon adverse effects of deprenyl are psychomotor agitation, irritability and insomnia. It is thought that these effects are derived because of the deprenyl catecholamine-enhancing effect. These ‘psychic’ effects can be dealt with by the consumption of magnesium.
Depenyl has become a famous and pertinent medication to treat ageing problems. It is a general drug for people who have exceeded 45 years of age. It treats individuals who are suffering from irrational depletion of dopamine.