Introduction to L-dopa (Levodopa)
Introduction to L-dopa (Levodopa)
There have been two nobel prizes offered in relation to L-dopa. Arvid Carlsson, received a Nobel Prize in 2000 and in 2001, William S. Knowles earned one-fourth of a Nobel Prize for Chemistry. The substance was found to have strong contribution to the alleviation and treatment against Parkinsonian symptoms. It was found that it tended to hinder the development of the symptoms themselves.
L-dopa (levodopa) was introduced to the market in the 1960s. It has mainly acted as the most appropriate therapy medicine for Parkinson’s disease. Levodopa, itself is a natural matter which is present both in animals and plants. L-dopa works in a specific way. Once it enters our blood it goes through the blood barriers found in the brain and is then decarboxylated. L-dopa is an amino acid which is converted to dopamine, once, in the brain. Levodopa is a precursor to the substance dopamine. The depletion of dopamine provokes Parkinson’s disease. L-dopa does perfectly focus on increasing the level of dopamine and thus as a consequence, it alleviates Parkinsonian symptoms.
Levodopa is sold as a prescribed drug and a dietary supplement in the United State of America. The drug has been administrated to treat Parkinson’s disease but there are also substances found in levodopa making it a marine adhesive (utilized by pelagic life).
Function and Mechanism of L-Dopa
L-Dopa is consumed orally. Once taken, levodopa, the substance will infiltrate into our biological system. It will effectively bypass the “blood-brain barriers”. Instantaneously as the drug crosses the blood-brain barriers it is converted to dopamine. The increasing rectification of the level of dopamine in the brain results in positive effect on our mental health. A higher intensification of dopamine is expected to recover the nerves. This very increase in dopamine assists in the treatment against Parkinson’s disease. However, dopamine is produced in other parts of our body as well. The dopamine produced in the various other parts is highly linked with adverse effects of levodopa.
Side-effects of L-dopa
There are various possible adverse reactions that can be experienced by L-dopa. A list of some of the possible consequences has been highlighted below:
- Hair loss
- Amidst some less common
Levodopa is considered to have relatively few side-effects to other drugs created for the same intention such as dopamine agonists and anticholinergics. These drugs carry more deleterious effect in the treatment for Parkinson. Moreover, the volume of the dosage consumed will also be a factor which will highly influence the risk of grapping any negative reactions.
Research on L-dopa
Research has proven l-dopa to be generally safe for humans. The various research has reported a rise in cytotoxicity makers in rats. Another report depicts that an enhancement of the development of ‘quinones’ through a rise in auto-oxidation and subsequent cell death in mesencephalic cell cultures. These are all positive figures drawn from the research upon l-dopa.
Interactions of L-dopa
L-dopa is sensitive to vitamins and other drugs. The presence of vitamine B6 can alter the efficiency of L-dopa. Large dosage of B6 should thus be avoided while consuming L-dopa. This minor problem can be evaded with the consumption of Sinemet. Furthermore, people who are using other drugs such as tyrosine or phenylalanine might be forced to take a higher intake. A Study has depicted that amino acids products compete among themselves and as a consequence the effectiveness of L-dopa is reduced. This can be accommodated by increasing the dosage of levodopa. A similar relation will sustain with high or low level of dietary protein intake. It is preferable to balance the diet in accordance to specifications of the medicine. It is thus necessary to consult a professional doctor before evaluating the necessary dose of l-dopa to be consumed.
General Information about L-Dopa
Levodopa does increase the concentration of dopamine. The consumption of levodopa together with carbidopa assures that l-dopa will properly enter into the brain. Cabidopa does thus allow users to consume lower volumes of the drug. This will restrain the risk of possible side-effects such as vomiting or nausea. The recommended combinations of drugs used together with levodopa are sinemet or atamet consumed concurrently with carbidopa. This is the standard prescription to levodopa.